Drug metabolism and pharmacokinetics
Burton, R. D., Hieronymus, T., Chamem, T., Heim, D., Anderson, S., Zhu, X., & Hutzler, J. M. (2018). Assessment of the Biotransformation of Low-Turnover Drugs in the H┬ÁREL Human Hepatocyte Coculture Model. Drug Metabolism and Disposition,46(11), 1617-1625
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Bonn, B., Svanberg, P., Janefeldt, A., Hultman, I., & Grime, K. (2016). Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG. Drug Metabolism and Disposition,44(4), 527-533. doi:10.1124/dmd.115.067769      
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Toxicology
Novik, E. I., Dwyer, J., Morelli, J. K., Parekh, A., Cho, C., Pludwinski, E., . . . Jayyosi, Z. (2017). Long-enduring primary hepatocyte-based co-cultures improve prediction of hepatotoxicity. Toxicology and Applied Pharmacology,336, 20-30. doi:10.1016/j.

     

Chan, R., & Benet, L. Z. (2018). Evaluation of the relevance of DILI predictive hypotheses in early drug development: Review of in vitro methodologies vs. BDDCS classification. Toxicology Research,7(3), 358-370. doi:10.1039/c8tx00016f      
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Hepatotropic disease
Winer, B. Y., Huang, T. S., Pludwinski, E., Heller, B., Wojcik, F., Lipkowitz, G. E., . . . Ploss, A. (2017). Long-term hepatitis B infection in a scalable hepatic co-culture system. Nature Communications,8(1). doi:10.1038/s41467-017-00200-8      
 

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